The science behind resveratrol.

Why resveratol is a powerful longevity supplement.

 
 

The highlights.

  • Activates longevity genes (sirtuins)

  • Synergistic with NAD+ boosters

  • Works as an antioxidant

  • Supports 7 Hallmarks of Ageing

  • Activates the sirtuins

    Resveratrol mimics calorie restriction and this activates longevity genes (the so-called sirtuins) that protect your DNA and epigenetics. Resveratrol works synergistically with NAD+ boosters - like NMN - that supply the fuel for these sirtuins.

  • Works as an antioxidant

    Resveratrol is a polyphenol, a naturally occurring highly powerful antioxidant. It is found in high quantities in grape skin, but can also be found in peanuts, berries and Japanese knotweed (Hu Zhang). Antioxidants are substances that may protect your cells against free radicals that cause diseases.

  • Synergistic with NAD+ boosters

    As resveratrol activates the sirtuins and NAD+ boosters provide fuel to these genes, resveratrol works synergistically with NAD+ boosters - like NMN. Resveratrol and NMN together cover all 9 Hallmarks of Ageing (the reasons why we age on a cellular level).

 

Is resveratrol proven to work?

Science is making a lot of progress in the longevity space and the proof is building up. Four reasons why resveratrol is a powerful longevity supplement:

  1. Resveratrol has antioxidant and anti-inflammatory properties to protect you against diseases like cancer, diabetes, and Alzheimer's disease. The anti-inflammatory effects of resveratrol make it a good remedy for arthritis, and skin inflammation.

  2. Resveratrol has boosted the lifespan of animals by 60%

  3. Human studies are proving resveratrol is safe to use and showing promising results

  4. Prominent researchers in the field, such as professor David Sinclair, are taking resveratrol themselves

 

Resveratrol is naturally-occurring in foods.

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a polyphenol, a compound that certain plants produce to defend themselves against pressures such as weather, insect attacks and wounding. Resveratrol is found in high concentrations in red grape skin, but also in peanuts, blueberries, raspberries, mulberries and Japanese knotweed (Hu Zhang).

Although our resveratrol is synthesised for purity and safety reasons, one 300 mg capsule of the The Grape - Resveratrol contains the equivalent amount of resveratrol as 43 liters of red grape juice (or 24 liters of red wine).

Resveratrol is one of the most-researched longevity supplements.

Resveratrol is the subject of many scientific studies and has gained a lot of popularity in the scene of early adopters and bio hackers. For Youth wants to unlock this knowledge and make this product available to everyone.

One of the biggest proponents of resveratrol is prof. David Sinclair of Harvard Medical School. In his book “Lifespan - Why we age and why we don’t have to” (2019) he describes the vast amount of research into this molecule, but also what it has done to him personally.

Resveratrol shows a wide range of effects in studies.

Resveratrol works holistically on your health and, therefore, studies show benefits on many fronts.

Support for heart and blood health seems to be the biggest benefit of resveratrol. It supports with lowering blood pressure and lowering blood fats.

It also protects the brain, increase insuline sensitivity and may ease joint pain.

On a cellular level, there is evidence that resveratrol even may surpress the cancerous cells.

Resveratrol targets 7 Hallmarks of Ageing.

Resveratrol targets 7 Hallmarks of Ageing (and combined with NMN, you would target them all).

  • Genomic instability: errors in your DNA

  • Telomere shortening: loss of DNA protection

  • Epigenetic alterations: genes are wrongly turned off or on

  • Loss of proteostasis: accumulation of proteins inside cells

  • Nutrient sensing: cells absorbing too many nutrients

  • Mitochondrial dysfunction: internal power plants breaking down

  • Cellular senescence: zombie cells

Learn more about the Hallmarks of Ageing here.

 

The Grape - Resveratrol

Resveratrol activates your longevity genes - or sirtuins. This supports a longer healthier life.

Read up on the science.

+ Health benefits of resveratrol

- Ramírez-Garza SL, Laveriano-Santos EP, Marhuenda-Muñoz M, Storniolo CE, Tresserra-Rimbau A, Vallverdú-Queralt A, Lamuela-Raventós RM. Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients. 2018 Dec 3;10(12):1892. doi: 10.3390/nu10121892. PMID: 30513922; PMCID: PMC6317057.

- Liu, Y., Ma, W., Zhang, P., He, S., & Huang, D. (2015). Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clinical nutrition (Edinburgh, Scotland), 34(1), 27–34. https://doi.org/10.1016/j.clnu.2014.03.009

- Xie HC, Han HP, Chen Z, He JP. A study on the effect of resveratrol on lipid metabolism in hyperlipidemic mice. Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):209-12. PMID: 24653579; PMCID: PMC3957267.

- Granzotto A, Zatta P. Resveratrol and Alzheimer's disease: message in a bottle on red wine and cognition. Front Aging Neurosci. 2014 May 14;6:95. doi: 10.3389/fnagi.2014.00095. PMID: 24860502; PMCID: PMC4030174.

- Vallianou NG, Evangelopoulos A, Kazazis C. Resveratrol and diabetes. Rev Diabet Stud. 2013 Winter;10(4):236-42. doi: 10.1900/RDS.2013.10.236. Epub 2014 Feb 10. PMID: 24841877; PMCID: PMC4160010.

- Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M. Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci. 2012;13(4):4202-32. doi: 10.3390/ijms13044202. Epub 2012 Mar 30. PMID: 22605974; PMCID: PMC3344210.

- Soleas, G. J., Grass, L., Josephy, P. D., Goldberg, D. M., & Diamandis, E. P. (2002). A comparison of the anticarcinogenic properties of four red wine polyphenols. Clinical biochemistry, 35(2), 119–124. https://doi.org/10.1016/s0009-9120(02)00275-8

+ Resveratrol increases lifespan

- Pallauf, K., Rimbach, G., Rupp, P. M., Chin, D., & Wolf, I. M. (2016). Resveratrol and Lifespan in Model Organisms. Current medicinal chemistry, 23(41), 4639–4680. https://doi.org/10.2174/0929867323666161024151233

+ Resveratrol is safe for human consumption

- Ramírez-Garza SL, Laveriano-Santos EP, Marhuenda-Muñoz M, Storniolo CE, Tresserra-Rimbau A, Vallverdú-Queralt A, Lamuela-Raventós RM. Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients. 2018 Dec 3;10(12):1892. doi: 10.3390/nu10121892. PMID: 30513922; PMCID: PMC6317057.

+ Resveratrol supports 7 Hallmarks of Ageing

- Matsuno, Y., Atsumi, Y., Alauddin, M., Rana, M. M., Fujimori, H., Hyodo, M., … & Nakatsu, Y. (2020). Resveratrol and its Related polyphenols contribute to the Maintenance of Genome Stability. Scientific Reports, 10(1), 1-10.

- Gutlapalli SD, Kondapaneni V, Toulassi IA, Poudel S, Zeb M, Choudhari J, Cancarevic I. The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling. Cureus. 2020 Nov 14;12(11):e11482. doi: 10.7759/cureus.11482. PMID: 33329978; PMCID: PMC7735524.

- Fernandes GFS, Silva GDB, Pavan AR, Chiba DE, Chin CM, Dos Santos JL. Epigenetic Regulatory Mechanisms Induced by Resveratrol. Nutrients. 2017 Nov 1;9(11):1201. doi: 10.3390/nu9111201. PMID: 29104258; PMCID: PMC5707673.

- Corpas, R., Griñán-Ferré, C., Rodríguez-Farré, E., Pallàs, M., & Sanfeliu, C. (2019). Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement. Molecular neurobiology, 56(2), 1502–1516. https://doi.org/10.1007/s12035-018-1157-y

- Pyo IS, Yun S, Yoon YE, Choi JW, Lee SJ. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases. Molecules. 2020 Oct 12;25(20):4649. doi: 10.3390/molecules25204649. PMID: 33053864; PMCID: PMC7587336.