The science behind quercetin.

Why quercetin is a powerful longevity supplement.

 
 

The highlights.

  • Clears senescent or zombie cells

  • Synergistic with NMN & resveratrol

  • Works as an antioxidant

  • Supports 7 Hallmarks of Ageing

  • Clears senescent cells

    Senescent cells - or Zombie cells - are cells that are not dead, but have stopped dividing. Senescent cells emit molecules that cause inflammation to the healthy cells around them. Quercetin is shown to be able to clear senescent cells and reduce inflammation.

  • Works as an antioxidant

    Flavonoids, such as quercetin, are antioxidants. They neutralise particles known as free radicals which damage cells, our DNA, and even cause cell death. This keeps our cells healthy.

  • Synergistic with NMN and resveratrol

    Quercetin and the NAD+ booster NMN together cover all 9 Hallmarks of Ageing (the reasons why we age on a cellular level). Quercetin has also shown to be more effective if taken in combination with resveratrol.

 

Is quercetin proven to work?

Science is making a lot of progress in the longevity space and the proof is building up. Four reasons why quercetin is a powerful longevity supplement:

  1. Quercetin is proven to be a senolytic, clearing senescent or zombie cells. This reduces the inflammation that is emitted by these non-functioning cells.

  2. Quercetin has antioxidant and anti-inflammatory properties to protect you against diseases like cancer, diabetes, and Alzheimer's disease. Quercetin stabilises the cells that release histamine in the body and can therefore be a remedy for allergies.

  3. Human studies are proving quercetin is safe to use and showing promising results

  4. Prominent researchers in the field, such as professor David Sinclair, are taking quercetin themselves

 

Quercetin is naturally-occurring in plants.

Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a flavonoid, a substance that gives colour to plants. Although the word “quercetin” is derived from the Latin word for oak, capers are by far the richest source of quercetin (234mg per 100g). Red onions come in second second with 32mg per 100g. In Traditional Chinese Medicine (TCM), quercetin is the active ingredient of Yang Yin Qing Fei Tang.

Our quercetin is obtained by hydrolising a sophora japonica flower extract. Sophora Japonica is also known as the Japanese pagoda tree.

One capsule of The Zombie roughly contains the same amount of quercetin as in 625g of red onions.

Quercetin is one of the most-researched longevity supplements.

Quercetin is the subject of many scientific studies and has gained a lot of popularity in the scene of early adopters and bio hackers. For Youth wants to unlock this knowledge and make this product available to everyone.

Quercetin shows a wide range of effects in studies.

Quercetin works holistically on your health by reducing inflammation and protecting the body against free radicals. Therefore, studies show benefits on many fronts.

Support for allergies seems to be the biggest benefit of quercetin. Human studies have shown that it can reduce allergy discomfort by 50-70%.

Another study showed better sports performance. After supplementation of quercetin, triathletes were quicker and recovered faster than the control group.

Other evidence suggests that quercetin helps to increase immunity against respiratory diseases.

On a cellular level, there is evidence that quercetin even may surpress the cancerous cells.

Quercetin targets 7 Hallmarks of Ageing.

Quercetin targets 7 Hallmarks of Ageing (and combined with NMN, you would target them all).

  • Genomic instability: errors in your DNA

  • Telomere shortening: loss of DNA protection

  • Epigenetic alterations: genes are wrongly turned off or on

  • Loss of proteostasis: accumulation of proteins inside cells

  • Nutrient sensing: cells absorbing too many nutrients

  • Mitochondrial dysfunction: internal power plants breaking down

  • Cellular senescence: zombie cells

Learn more about the Hallmarks of Ageing here.

 

The Zombie - Quercetin

Quercetin clears your zombie cells. This supports a longer healthier life.

Read up on the science.

+ Quercetin as a senolytic and antioxidant

-Zhu, Y., et al. (2015), The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell, 14: 644-658. https://doi.org/10.1111/acel.12344 -Hunter P. (2012). The inflammation theory of disease. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment. EMBO reports, 13(11), 968–970. https://doi.org/10.1038/embor.2012.142

-Boots, A. W., Haenen, G. R., & Bast, A. (2008). Health effects of quercetin: from antioxidant to nutraceutical. European journal of pharmacology, 585(2-3), 325–337. https://doi.org/10.1016/j.ejphar.2008.03.008

-Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J., … Kirkland, J. L. (2018). Senolytics improve physical function and increase lifespan in old age. Nature medicine, 24(8), 1246–1256. https://doi.org/10.1038/s41591-018-0092-9

-Sohn, E. J., Kim, J. M., Kang, S. H., Kwon, J., An, H. J., Sung, J. S., Cho, K. A., Jang, I. S., & Choi, J. S. (2018). Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts. The American journal of Chinese medicine, 46(4), 853–873. https://doi.org/10.1142/S0192415X18500453

+ Quercetin alleviates allergies

-Mlcek, J., Jurikova, T., Skrovankova, S., & Sochor, J. (2016). Quercetin and Its Anti-Allergic Immune Response. Molecules (Basel, Switzerland), 21(5), 623. https://doi.org/10.3390/molecules21050623

-Shaik, Y. B., Castellani, M. L., Perrella, A., Conti, F., Salini, V., Tete, S., Madhappan, B., Vecchiet, J., De Lutiis, M. A., Caraffa, A., & Cerulli, G. (2006). Role of quercetin (a natural herbal compound) in allergy and inflammation. Journal of biological regulators and homeostatic agents, 20(3-4), 47–52.

-Shishehbor, F., Behroo, L., Ghafouriyan Broujerdnia, M., Namjoyan, F., & Latifi, S. M. (2010). Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iranian journal of allergy, asthma, and immunology, 9(1), 27–34.

+ Quercetin health benefits on immunity, sports performance, and other issues

-Di Pierro F, Derosa G, Maffioli P, Bertuccioli A, Togni S, Riva A, Allegrini P, Khan A, Khan S, Khan BA, Altaf N, Zahid M, Ujjan ID, Nigar R, Khushk MI, Phulpoto M, Lail A, Devrajani BR, Ahmed S. Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study. Int J Gen Med. 2021 Jun 8;14:2359-2366. doi: 10.2147/IJGM.S318720. PMID: 34135619; PMCID: PMC8197660.

-Di Pierro F, Iqtadar S, Khan A, Ullah Mumtaz S, Masud Chaudhry M, Bertuccioli A, Derosa G, Maffioli P, Togni S, Riva A, Allegrini P, Khan S. Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial. Int J Gen Med. 2021 Jun 24;14:2807-2816. doi: 10.2147/IJGM.S318949. PMID: 34194240; PMCID: PMC8238537.

-Rondanelli, M., Perna, S., Gasparri, C., Petrangolini, G., Allegrini, P., Cavioni, A., Faliva, M. A., Mansueto, F., Patelli, Z., Peroni, G., Tartara, A., & Riva, A. (2022). Promising Effects of 3-Month Period of Quercetin Phytosome® Supplementation in the Prevention of Symptomatic COVID-19 Disease in Healthcare Workers: A Pilot Study. Life (Basel, Switzerland), 12(1), 66. https://doi.org/10.3390/life12010066

-Costa, L. G., Garrick, J. M., Roquè, P. J., & Pellacani, C. (2016). Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More. Oxidative medicine and cellular longevity, 2016, 2986796. https://doi.org/10.1155/2016/2986796

-Cesarone, M. R., Belcaro, G., Hu, S., Dugall, M., Hosoi, M., Ledda, A., Feragalli, B., Maione, C., & Cotellese, R. (2019). Supplementary prevention and management of asthma with quercetin phytosome: a pilot registry. Minerva medica, 110(6), 524–529. https://doi.org/10.23736/S0026-4806.19.06319-5

-Riva, A., Vitale, J. A., Belcaro, G., Hu, S., Feragalli, B., Vinciguerra, G., Cacchio, M., Bonanni, E., Giacomelli, L., Eggenhöffner, R., & Togni, S. (2018). Quercetin phytosome® in triathlon athletes: a pilot registry study. Minerva medica, 109(4), 285–289. https://doi.org/10.23736/S0026-4806.18.05681-1

-Pérez-Vizcaíno, F., Ibarra, M., Cogolludo, A. L., Duarte, J., Zaragozá-Arnáez, F., Moreno, L., López-López, G., & Tamargo, J. (2002). Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. The Journal of pharmacology and experimental therapeutics, 302(1), 66–72. https://doi.org/10.1124/jpet.302.1.66

+ Quercetin in combination with resveratrol

-Singh, V., Singh, R., Kujur, P. K., & Singh, R. P. (2020). Combination of Resveratrol and Quercetin Causes Cell Growth Inhibition, DNA Damage, Cell Cycle Arrest, and Apoptosis in Oral Cancer Cells. Assay and drug development technologies, 18(5), 226–238. https://doi.org/10.1089/adt.2020.972

-Zhao, L., Cen, F., Tian, F., Li, M., Zhang, Q., Shen, H. ... Du, J. (2017). Combination treatment with quercetin and resveratrol attenuates high fat diet‑induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 signaling pathway. Experimental and Therapeutic Medicine, 14, 5942-5948. https://doi.org/10.3892/etm.2017.5331

+ Quercetin is safe for human consumption

-Andres, S., Pevny, S., Ziegenhagen, R., Bakhiya, N., Schäfer, B., Hirsch-Ernst, K. I., & Lampen, A. (2018). Safety Aspects of the Use of Quercetin as a Dietary Supplement. Molecular nutrition & food research, 62(1), 10.1002/mnfr.201700447. https://doi.org/10.1002/mnfr.201700447

+ Quercetin supports 7 Hallmarks of Ageing

-Pallauf, K., Rimbach, G., Rupp, P. M., Chin, D., & Wolf, I. M. (2016). Resveratrol and Lifespan in Model Organisms. Current medicinal chemistry, 23(41), 4639–4680. https://doi.org/10.2174/0929867323666161024151233

-Abharzanjani, F., Afshar, M., Hemmati, M., & Moossavi, M. (2017). Short-term High Dose of Quercetin and Resveratrol Alters Aging Markers in Human Kidney Cells. International journal of preventive medicine, 8, 64. https://doi.org/10.4103/ijpvm.IJPVM_139_17

+ Quercetin phytosome is absorbed 20x better

-Riva A, Ronchi M, Petrangolini G, Bosisio S, Allegrini P. Improved Oral Absorption of Quercetin from Quercetin Phytosome®, a New Delivery System Based on Food Grade Lecithin. Eur J Drug Metab Pharmacokinet. 2019 Apr;44(2):169-177. doi: 10.1007/s13318-018-0517-3. PMID: 30328058; PMCID: PMC6418071.